随机复杂结构与数据科学重点实验室/统计科学研究中心
学术报告


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Speaker:

Prof. Sijian Wang,Rutgers University

Inviter: 孙六全 研究员
Title:
X-ray crystallography, Cryo-EM, protein data bank and some statistical questions
Time & Venue:

2018.9.21 16:00 N613

Abstract:
Protein is an important component of every cell in the body and is an important building block of bones, muscles, cartilage, skin, and blood. The knowledge of a high resolution atomic structure of a target protein is an essential pre-requisite for understanding biological activities of the protein and all structure-based biomedical research and structure-based drug design.
The Protein Data Bank (PDB) provides a rich resource on archive-information about the 3D shapes of proteins, nucleic acids, and complex assemblies that helps researchers understand all aspects of biomedicine and agriculture, from protein synthesis to health and disease. The RCSB PDB hosted by Rutgers also takes in charge of curating and annotating PDB data.
Statistics plays an important role in many structure-related research. In this talk, I will describe some statistical applications and statistical questions when we analyze PDB data, including crystallization condition parsing, fitting and refinement of structure model, quality control of PDB structures, structure classification/clustering in PDB and automatic biological assembly annotation.
Affiliation:  

学术报告中国科学院数学与系统科学研究院应用数学研究所
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